SEQUENCE OF MURINE CORONAVIRUS JHM INDUCED NEUROPATHOLOGICAL CHANGES IN RATS
نویسندگان
چکیده
منابع مشابه
Structural polypeptides of the murine coronavirus JHM.
Analysis by SDS-polyacrylamide gel electrophoresis shows that the purified coronavirus JHM contains six polypeptides. The apparent mol. wt. of the polypeptides (GP1, GP2, GP3, VP4, GP5 and VP6) are 170000; 125000; 97500; 60800; 24800 and 22700, respectively. Four polypeptides are glycosylated (GP1, GP2, GP3 and GP5). The analysis of particles obtained after limited proteolysis with pronase sugg...
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Inducibility of Ia molecules on cultivated astrocytes by JHM virus correlates with demyelinating disease susceptibility of animals from which these astrocytes are derived. On the contrary, class I induction of both astrocytes and oligodendrocytes occurs as a consequence of normal cultivation procedures in both susceptible and resistant strains. Increased expression of class I antigens on rat as...
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To analyze the pathogenesis of the neurotropic murine coronavirus JHMV, we used monoclonal antibodies to the E2 viral glycoprotein to select antigenic variant viruses. Monoclonal antibodies J.7.2 and J.2.2 were shown to bind to topographically distinct regions of the E2 molecule, and the variants selected with the two antibodies demonstrated very different disease pictures in mice. Variants sel...
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ژورنال
عنوان ژورنال: Neuropathology and Applied Neurobiology
سال: 1984
ISSN: 0305-1846,1365-2990
DOI: 10.1111/j.1365-2990.1984.tb00350.x